We've gone through them all to help you find the right flight for you. If you can't find what you're looking for, consider widening your search by looking at flights from a different airport.
But when you fly is just as important as where you fly from. Search by month to find out when flights are at the priciest and their cheapest.
Last-minute deals can be cheaper, but it's risky. It's best to book flights to Sao Tome and Principe in advance to avoid disappointment.
Did you know you can also compare hotel and car hire prices in Portugal with Netflights? Take a look to get an idea of prices in Sao Tome and Principe.