Cheap flights from Manchester to St Louis

from as little as £902

12 nights in St Louis, departing Manchester on 03 / Sep / 2025 with Virgin Atlantic (price found 1 hour ago)

Subject to availability, prices correct of the last 24 hours
St Louis

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The Manchester / St Louis route

All 6546 km of it

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St Louis flight facts

What you need to know

Alternative flights from the UK to St Louis

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St Louis

Today alone, Netflights has searched over 740 flights. 03 / Sep / 2025 is currently the lowest priced day of the year to fly the Manchester/St Louis route. There are around 77 flights on any given week from the UK to St Louis and the cheapest month to fly right now is September.

Not suitable? Try running another search or viewing all cheap flight deals.

Min / Max Temperature (°C)
LOWEST

-5 °C

AVG

14 °C

HIGHEST

32 °C

Rainfall (mm)
LOWEST

56 mm

AVG

92.9 mm

HIGHEST

116 mm

Key facts about St Louis

How to get cheap flights from Manchester to St Louis

Tips and advice from our flight experts

You’ve searched for flights from Manchester to St Louis. 77 flights go to or via St Louis every week, and we've searched them all to make it easy for you to compare your flight options. On average, Virgin Atlantic has the cheapest flights, so look out for them in your search results.

When you fly 6546 km from Manchester to St Louis, you can choose from three airlines. Flights are most expensive during high season, and you can expect accommodation prices to be higher then too. Last-minute deals do crop up, but it's best to book in advance to avoid disappointment.

To sort cheap flights to St Louis, it's best to start searching for flights by month, as this will show you when prices are at their lowest. Keep an eye on Virgin Atlantic too, as they're the most popular airline for flying from Manchester to St Louis.

It takes about 13 hrs 55 mins to fly from Manchester to St Louis. Once you’ve chosen your flight, go through and fill out your details to complete your booking. If you haven’t yet sorted your hotel or car hire, take a look at our competitive rates – then you can book your flights and accommodation in one go.

Other popular destinations near St Louis

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