There are 58 direct and indirect flights connecting Southampton and Chicago every week, with the journey taking 13 hrs 5 mins on average. Scroll through your results to compare flight times and prices – the cheapest flight from Southampton to Chicago is currently sitting at £747.
Or, if you're fairly flexible on dates, try to get a last minute-deal by regularly checking the Netflights website.
Chicago actually has two airports to choose from – but Chicago O'hare International Airport (ORD) is the usually the cheapest option. If you need to fly into a specific airport, adjust your search to focus on those flights. The most popular airlines include Virgin Atlantic, Aer Lingus & KLM.
But if you can't find one which is right for you, try looking at flights to other cities in the USA to check out some other options.