There are 92 direct and indirect flights connecting Southampton and Chicago every week, with the journey taking 13 hrs 20 mins on average. Scroll through your results to compare flight times and prices – the cheapest flight from Southampton to Chicago is currently sitting at £654.
Or, if you're fairly flexible on dates, try to get a last minute-deal by regularly checking the Netflights website.
Chicago actually has two airports to choose from – but Chicago O'hare International Airport (ORD) is the usually the cheapest option. If you need to fly into a specific airport, adjust your search to focus on those flights. The most popular airlines include British Airways, Aer Lingus & Virgin Atlantic.
But if you can't find one which is right for you, try looking at flights to other cities in the USA to check out some other options.